Introduction to mechanobiology

Week 1

Lecture 1: Need to study Mechanobiology

Lecture 2: Cell as a Tent, individual components

Lecture 3: Cell-ECM crosstalk

Lecture 4: ECM proteins: Collagen

Lecture 5: Measuring properties of collagen networks

Week 2

Lecture 6: Properties of collagen networks

Lecture 7: Rheology

Lecture 8: Rheology of biopolymer networks

Lecture 9: Atomic Force Microscopy (AFM)

Lecture 10: Design of protein constructs for AFM

Week 3

Lecture 11: Protein unfolding using AFM

Lecture 12: Protein unfolding using AFM

Lecture 13: Focal adhesions: focal adhesion proteins

Lecture 14: Focal adhesion organization

Lecture 15: Focal adhesions: role of forces

Week 4

Lecture 16: Cytoskeleton: Actin

Lecture 17: Force-velocity relationships of actin networks

Lecture 18: Mesenchymal cell migration

Lecture 19: Actin dynamics during mesenchymal migration

Lecture 20: Actin dynamics during mesenchymal migration

Week 5

Lecture 21: Adhesion Independent Migration

Lecture 22: Adhesion Independent & Collective Cell Migration

Lecture 23: Collective Cell Migration

Lecture 24: Mechanobiology of Stem Cell Fate - I

Lecture 25: Mechanobiology of Stem Cell Fate - II

Week 6

Lecture 26: Mechanobiology of Stem Cell Fate - III

Lecture 27: Mechanobiology of Diseases: Cancer I

Lecture 28: Mechanobiology of Diseases: Cancer II

Lecture 29: Mechanobiology of Diseases: Cancer III

Lecture 30: Mechanobiology of Diseases: Atherosclerosis & Hypertension

Week 7

Lecture 31: Mechanobiology of Diseases: Muscular Dystrophy

Lecture 32: Nuclear Mechanotransduction: LINC complex

Lecture 33: Nuclear Mechanotransduction: LINC complex in cell migration

Lecture 34: Nuclear Mechanotransduction: Gene regulation

Lecture 35: Mechanical Forces & DNA damage

Week 8

Lecture 36: Techniques in Mechanobiology: Hydrogels

Lecture 37: Techniques in Mechanobiology: AFM

Lecture 38: Techniques in Mechanobiology: Traction Force Microscopy, Trypson Deadhesion & Laser Ablation

Lecture 39: Techniques in Mechanobiology: Microfabrication

Lecture 40: Techniques in Mechanobiology: FRE