Metal Mediated Synthesis-I

Metal Mediated Synthesis-I by Indian Institute of Technology Bombay

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Created by IIT Bombay Staff Last updated Tue, 29-Mar-2022 English


Metal Mediated Synthesis-I free videos and free material uploaded by IIT Bombay Staff .

Syllabus / What will i learn?

Week 1 :
Lecture 1: Assymetric

Lecture 2: Transition metal carbenes,Fischer and Schrock carbenes

Lecture 3: Olefin metathesis

Lecture 4: Alkyne metathesis

Lecture 5: Cyclopropanation reaction

Week 2 :
Lecture 6: Catalytic cyclopropanation reaction,Introduction to cross coupling reaction

Lecture 7: Kumada Coupling reaction

Lecture 8: Suzuki coupling reaction

Lecture 9: Stille coupling reaction

Lecture 10:Assymetric Suzuki coupling reaction
Week 3 :
Lecture 11: Sonogashira coupling reaction

Lecture 12: Heck coupling reaction

Lecture 13: Assymetric Heck reaction,Introduction to Buchwald-Hartwig coupling reaction

Lecture 14: Buchwald-Hartwig coupling reaction

Lecture 15: Role of Ligands its influence in Buchwald-Hartwig coupling reaction
Week 4 :
Lecture 16: Oxidative cyclization process

Lecture 17: Application of oxidative cyclization in natural product synthesis

Lecture 18: Synthesis of reactive metallacycle intermediate via-Beta-abstraction and their applications

Lecture 19: Kulinkovich Reaction and its mechanism

Lecture 20: Pauson–Khand reaction



Curriculum for this course
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Description

The course covers an advance level of organometallic chemistry. Recent development of cross coupling reactions and their applications in organic synthesis, starting from small molecule to naturally and pharmaceutically important compounds, has been described in the prescribed course. In this course, a brief overview about the carbine chemistry and oxidative cyclization is also portrayed.

INTENDED AUDIENCE: Students, PhD scholars, teachers, industry.

PREREQUISITES: Advance Organic and Inorganic Chemistry.

INDUSTRY SUPPORT: All Pharmaceutical Industries.

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Free

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