Understanding Cancer Metastasis

History and Overview of Metastasis

In this first module, we'll concentrate on the history and overview of metastasis and give you a flavor of how cancer is defined as well as some of the history surrounding how we began to understand metastasis

Primary Tumor Growth and Neoangiogenesis

In this module, we'll focus on uncontrolled cell division, which is a defining property of cancer, as well as mutation and neoangiogenesis and their roles in tumor formation We'll also take a look at a primary tumor microenvironment and its component cell types

EMT / Invasion / Intravasation

During this module, we'll turn our attention to the next steps after the initial primary tumor formation, epithelial to mesenchymal transition of cancer cells, and local tumor invasion and intravasation into blood or lymph vessels

Survival in the Circulation and Extravasation

We'll now take a close look at cancer survival within the circulation, the role of the circulatory system in metastasis, the genetic determinants of metastatic potential, signalling mechanisms, chemokines, the dock and lock hypothesis, and extravasation

Dormancy and Secondary Tumor Growth

In this module, we'll focus on dormancy and secondary tumor growth and how they contribute to the lethality of cancer

Morbidity and Mortality Associated with Metastasis

In the previous modules, we've looked closely at the sequential steps of metastasis and some of the biology of how metastasis occurs Now, we'll turn our attention to morbidity and mortality, or in other words, how cancer hurts and kills people