Essentials of Biomolecules : Nucleic Acids and Peptides free videos and free material uploaded by Guwahati Staff .
Week 1: Introduction, Nucleic acids and proteins
Week 2: Synthesis of nucleobases, nucleotides and oligonucleotides
Week 3: Solid phase synthesis of oligonucleotides
Week 4: DNA replication, Polymerases, DNA sequencing and PCR
Week 5: DNA damage, mutations and cancer
Week 6: DNA to proteins: transcription, translation and genetic code
Week 7: Peptides, sequencing and applications in therapeutics
Week 8: Solution phase and solid phase peptide synthesis
Week 9: Expansion of genetic code: PNA, LNA and molecular probes
Week 10: Modern techniques for biomolecules and disease diagnosis
Week 11: Structures and chemistry of sugars and carbohydrates
Week 12: Carbohydrate based polymers as biomolecular probes and therapeutics; conclusion
The proposed course aims to provide essentials of chemistry and biology of two very important class of biomolecules: nucleic acids (DNA/RNA) and proteins. The course allows to decipher: how structural features are translated into biological functions; how highly organized and selective chemical reactions are adopted that allows DNA to replicate or dictates step-wise synthesis of specific sequence of proteins; how organic chemistry tools in combination with enzymes were ingeniously applied to determine sequences of DNA and proteins and how chemical modifications could be done to mimic similar biological properties. The course also includes modern techniques, development of biomolecular probes as high-throughput detection of biomolecules, single nucleotide polymorphisms and disease diagnosis. Overall, the course falls within the domain of organic chemistry and chemical biology.
INTENDED AUDIENCE : For chemistry, Biochemistry and Biotechnology students
PREREQUISITES : Basic knowledge in organic chemistry
INDUSTRY SUPPORT : All major pharmaceuticals and Biotech companies
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