Systems Biology free videos and free material uploaded by Massachusetts Institute of Technology Staff .
Introduction to the class and overview of topics. Basic concepts in
networks and chemical reactions.
Input function of a gene, Michaelis-Menten kinetics, and cooperativity
Autoregulation, feedback and bistability
Introduction to synthetic biology and stability analysis in the toggle
switch
Oscillatory genetic networks
Graph properties of transcription networks
Feed-forward loop network motif
Introduction to stochastic gene expression
Causes and consequences of stochastic gene expression
Stochastic modeling—The master equation, Fokker-Planck Equation, and the
Gillespie algorithm
Life at low Reynolds number
Robustness and bacterial chemotaxis
No Lecture
Robustness in development and pattern formation
Introduction to microbial evolution experiments, and optimal gene
circuit design
Evolution in finite populations, genetic drift, and the theory of
neutral molecular evolution
Clonal interference and the distribution of beneficial mutations
Fitness landscapes and sequence spaces
Evolutionary games
No Lecture
Survival in fluctuating environments
Parasites, the evolution of virulence and sex
Interspecies interactions, the Lotka-Volterra model, and predator-prey
oscillations
Ecosystem stability, critical transitions, and the maintenance of
biodiversity
Dynamics of populations in space
The neutral theory of ecology
This course provides an introduction to cellular and population-level systems biology with an emphasis on synthetic biology, modeling of genetic networks, cell-cell interactions, and evolutionary dynamics. Cellular systems include genetic switches and oscillators, network motifs, genetic network evolution, and cellular decision-making. Population-level systems include models of pattern formation, cell-cell communication, and evolutionary systems biology.
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