Organic Chemistry in Biology and Drug Development

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1 / Organic Chemistry in Biology and Drug Development

2 / Lecture 1 : A brief introduction to Molecules of Life

3 / Lecture 2 : Biological Macro molecules and Small molecules: Importance and functions

4 / Lecture 3 : Amino Acids: The building block of proteins

5 / Lecture 4 : Amino acids: separation and detection, Electrophoresis and Ninhydrin reaction

6 / Lecture 5 : Method of determination of Amino acid sequence: primary structure of polypeptide/protein

7 / Lecture 6 : Selective peptide bond cleavage: Enzymatic and Non-enzymatic methods

8 / Lecture 7 : Peptide synthesis: Protecting groups for amine and carboxyl functionality

9 / Lecture 8 : Peptide synthesis (continued): Protection, coupling and deprotection methods

10 / Lecture 9 : Recent development of coupling agents;

11 / Lecture 10 : Hierarchial structure of proteins: Secondary, tertiary and quaternary structure

12 / Lecture 11 : Ramachandran plot and protein purification techniques

13 / Lecture 12 : Protein Purification Techniques (Contd.)

14 / Lecture 13 : Introduction to Enzymes and its kinetics

15 / Lecture 14 : Enzyme catalysed reactions and introduction to catalytic activity of proteases

16 / Lecture 15 : Enzyme Kinetics (Contd.)

17 / Lecture 16 : Concept of Enzyme Inhibition

18 / Lecture 17 : Concept of Enzyme Inhibition (Contd.)

19 / Lecture 18 : Problems on Enzyme Kinetics and Enzyme Inhibition

20 / Lecture 19 : Synthetic Biology

21 / Lecture 20 : Synthetic Biology (Contd.)

22 / Lecture 21 : Synthetic Biology (Contd.)

23 / Lecture 22 : Nucleic Acid

24 / Lecture 23 : Nucleic Acid (Contd.)

25 / Lecture 24 : DNA sequencing method

26 / Lecture 25 : DNA sequencing method (Contd.)

27 / Lecture 26 : DNA sequencing method (Contd.)

28 / Lecture 27 : Synthesis of oligonucleotide

29 / Lecture 28 : Central dogma: DNA replication, transcription and translation

30 / Lecture 29 : Central dogma: DNA replication, transcription and translation (Contd.)

31 / Lecture 30 : Central dogma: DNA replication, transcription and translation (Contd.)

32 / Lecture 31 : Central dogma: DNA replication, transcription and translation ((Contd.)

33 / Lecture 32 : Central dogma: DNA replication, transcription and translation (Contd.)

34 / Lecture 33 : Molecular Biology

35 / Lecture 34 : Molecular Biology (Contd.)

36 / Lecture 35 : Chemistry of cofactors/coenzymes

37 / Lecture 36 : Chemistry of cofactors/coenzymes (Contd.)

38 / Lecture 37 : Chemistry of cofactors/coenzymes (Contd.)

39 / Lecture 38 : Chemistry of cofactors/coenzymes (Contd.)

40 / Lecture 39 : Chemistry of cofactors/coenzymes (Contd.)

41 / Lecture 40 : Chemistry of cofactors/coenzymes (Contd.)

42 / Lecture-41: " Introduction to Drug Discovery Process"

43 / Lecture-42: " Fundamental Principles of Drug Development Process"

44 / Lecture-43: " Combinatorial chemistry"

45 / Lecture-44: "Neurotransmitters"

46 / Lecture-45: " Catechol amine based and GABA neurotransmitters"

47 / Lecture-46: " Hypertension: humoral mechanism and renin/angiotensin system"

48 / Lecture-47: " Inhibitor design of angiotensin converting enzyme"

49 / Lecture 48: Antimicrobial drugs

50 / Lecture 49: Chemistry of penicillins

51 / Lecture 50: Resistance to beta-lactam antibiotics

52 / Lecture 51: Mechanistic studies of beta-lactamase

53 / Lecture 52: Non beta-lactam antibiotics

54 / Lecture 53: Mechanistic enzymology of Isopenicillin N synthase

55 / Lecture-54 : Polyketide Biosynthesis

56 / Lecture 55 : Biosynthesis of macrolide polyketides and introduction to virus

57 / Lecture 56 : Anti-viral drugs

58 / Lecture-57 : Cancer and Chemotherapy

59 / Lecture-58 : Anti-cancer drugs (contd)

60 / Lecture 59 : Aromatase inhibition and Anti-ulcer drugs

61 / Lecture-60 : Cholesterol lowering agents

62 / Lecture 61 : Cholesterol Biosynthesis

63 / Lecture-62 : Pharmakinetics and pharmadynamics

64 / Lecture-63 : QSAR principles