Organic Chemistry in Biology and Drug Development in iit kharagpur
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1 / Organic Chemistry in Biology and Drug Development
2 / Lecture 1 : A brief introduction to Molecules of Life
3 / Lecture 2 : Biological Macro molecules and Small molecules: Importance and functions
4 / Lecture 3 : Amino Acids: The building block of proteins
5 / Lecture 4 : Amino acids: separation and detection, Electrophoresis and Ninhydrin reaction
6 / Lecture 5 : Method of determination of Amino acid sequence: primary structure of polypeptide/protein
7 / Lecture 6 : Selective peptide bond cleavage: Enzymatic and Non-enzymatic methods
8 / Lecture 7 : Peptide synthesis: Protecting groups for amine and carboxyl functionality
9 / Lecture 8 : Peptide synthesis (continued): Protection, coupling and deprotection methods
10 / Lecture 9 : Recent development of coupling agents;
11 / Lecture 10 : Hierarchial structure of proteins: Secondary, tertiary and quaternary structure
12 / Lecture 11 : Ramachandran plot and protein purification techniques
13 / Lecture 12 : Protein Purification Techniques (Contd.)
14 / Lecture 13 : Introduction to Enzymes and its kinetics
15 / Lecture 14 : Enzyme catalysed reactions and introduction to catalytic activity of proteases
16 / Lecture 15 : Enzyme Kinetics (Contd.)
17 / Lecture 16 : Concept of Enzyme Inhibition
18 / Lecture 17 : Concept of Enzyme Inhibition (Contd.)
19 / Lecture 18 : Problems on Enzyme Kinetics and Enzyme Inhibition
20 / Lecture 19 : Synthetic Biology
21 / Lecture 20 : Synthetic Biology (Contd.)
22 / Lecture 21 : Synthetic Biology (Contd.)
23 / Lecture 22 : Nucleic Acid
24 / Lecture 23 : Nucleic Acid (Contd.)
25 / Lecture 24 : DNA sequencing method
26 / Lecture 25 : DNA sequencing method (Contd.)
27 / Lecture 26 : DNA sequencing method (Contd.)
28 / Lecture 27 : Synthesis of oligonucleotide
29 / Lecture 28 : Central dogma: DNA replication, transcription and translation
30 / Lecture 29 : Central dogma: DNA replication, transcription and translation (Contd.)
31 / Lecture 30 : Central dogma: DNA replication, transcription and translation (Contd.)
32 / Lecture 31 : Central dogma: DNA replication, transcription and translation ((Contd.)
33 / Lecture 32 : Central dogma: DNA replication, transcription and translation (Contd.)
34 / Lecture 33 : Molecular Biology
35 / Lecture 34 : Molecular Biology (Contd.)
36 / Lecture 35 : Chemistry of cofactors/coenzymes
37 / Lecture 36 : Chemistry of cofactors/coenzymes (Contd.)
38 / Lecture 37 : Chemistry of cofactors/coenzymes (Contd.)
39 / Lecture 38 : Chemistry of cofactors/coenzymes (Contd.)
40 / Lecture 39 : Chemistry of cofactors/coenzymes (Contd.)
41 / Lecture 40 : Chemistry of cofactors/coenzymes (Contd.)
42 / Lecture-41: " Introduction to Drug Discovery Process"
43 / Lecture-42: " Fundamental Principles of Drug Development Process"
44 / Lecture-43: " Combinatorial chemistry"
45 / Lecture-44: "Neurotransmitters"
46 / Lecture-45: " Catechol amine based and GABA neurotransmitters"
47 / Lecture-46: " Hypertension: humoral mechanism and renin/angiotensin system"
48 / Lecture-47: " Inhibitor design of angiotensin converting enzyme"
49 / Lecture 48: Antimicrobial drugs
50 / Lecture 49: Chemistry of penicillins
51 / Lecture 50: Resistance to beta-lactam antibiotics
52 / Lecture 51: Mechanistic studies of beta-lactamase
53 / Lecture 52: Non beta-lactam antibiotics
54 / Lecture 53: Mechanistic enzymology of Isopenicillin N synthase
55 / Lecture-54 : Polyketide Biosynthesis
56 / Lecture 55 : Biosynthesis of macrolide polyketides and introduction to virus
57 / Lecture 56 : Anti-viral drugs
58 / Lecture-57 : Cancer and Chemotherapy
59 / Lecture-58 : Anti-cancer drugs (contd)
60 / Lecture 59 : Aromatase inhibition and Anti-ulcer drugs
61 / Lecture-60 : Cholesterol lowering agents
62 / Lecture 61 : Cholesterol Biosynthesis
63 / Lecture-62 : Pharmakinetics and pharmadynamics
64 / Lecture-63 : QSAR principles
Organic Chemistry in Biology and Drug Development in iit kharagpur
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